Results on entire solutions for a degenerate critical elliptic equation with anisotropic coefficients

In this paper, we study the following degenerate critical elliptic equations with anisotropic coefficients $$-div(|x_{N}|^{2\alpha}\nabla u)=K(x)|x_{N}|^{\alpha\cdot 2^{*}(s)-s}|u|^{2^{*}(s)-2}u {in} \mathbb{R}^{N}$$ where $x=(x_{1},...,x_{N})\in\mathbb{R}^{N},$ $N\geq 3,$ $\alpha>1/2,$ $0\leq s\leq 2$ and $2^{*}(s)=2(N-s)/(N-2).$ Some basic properties of the degenerate elliptic operator $-div(|x_{N}|^{2\alpha}\nabla u)$ are investigated and some regularity, symmetry and uniqueness results for entire solutions of this equation are obtained. We also get some variational identities for solutions of this equation. As a consequence, we obtain some nonexistence results for solutions of this equation.Comment: 29 page

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stably expressing the GH receptor (293GHR), HuH7 (hepatoma) and T-47D (breast cancer) cells. 293GHR cells were transiently transfected with an estrogen receptor-α expression plasmid and luciferase reporters with binding elements for STAT3 and STAT5 or the β-casein promoter. GH stimulated the reporter activities by four- to sixfold. Cotreatment with 17β-estradiol (E2) resulted in a dose-dependent reduction in the response of all three reporters to GH to a maximum of 49-66% of control at 100 nM (P < 0.05). No reduction was seen when E2 was added 1-2 h after GH treatment. Similar inhibitory effects were observed in HuH7 and T-47D cells. E2 suppressed GH-induced JAK2 phosphorylation, an effect attenuated by actinomycin D, suggesting a requirement for gene expression. Next, we investigated the role of the suppressors of cytokine signaling (SOCS) in E2 inhibition. E2 increased the mRNA abundance of SOCS-2 but not SOCS-1 and SOCS-3 in HEK293 cells. The inhibitory effect of E2 was absent in cells lacking SOCS-2 but not in those lacking SOCS-1 and SOCS-3. In conclusion, estrogen inhibits GH signaling, an action mediated by SOCS-2. This paper provides evidence for regulatory interaction between a sex steroid and the GH/JAK/STAT pathway, in which SOCS-2 plays a central mechanistic role

Forests, bioenergy and climate change mitigation: are the worries justified?

No abstract availabl

Altered Metabolism of Growth Hormone Receptor Mutant Mice: A Combined NMR Metabonomics and Microarray Study

Growth hormone is an important regulator of post-natal growth and metabolism. We have investigated the metabolic consequences of altered growth hormone signaling in mutant mice that have truncations at position 569 and 391 of the intracellular domain of the growth hormone receptor, and thus exhibit either low (around 30% maximum) or no growth hormone-dependent STATS signaling respectively. These mutants result in altered liver metabolism, obesity and insulin resistance

Forests, bioenergy and climate change mitigation: are the worries justified?

No abstract availabl

Status and prospects for renewable energy using wood pellets from the southeastern United States

The ongoing debate about costs and benefits of wood-pellet based bioenergy production in the southeastern United States (SE USA) requires an understanding of the science and context influencing market decisions associated with its sustainability. Production of pellets has garnered much attention as US exports have grown from negligible amounts in the early 2000s to 4.6 million metric tonnes in 2015. Currently, 98% of these pellet exports are shipped to Europe to displace coal in power plants. We ask, ‘How is the production of wood pellets in the SE USA affecting forest systems and the ecosystem services they provide?’ To address this question, we review current forest conditions and the status of the wood products industry, how pellet production affects ecosystem services and biodiversity, and what methods are in place to monitor changes and protect vulnerable systems. Scientific studies provide evidence that wood pellets in the SE USA are a fraction of total forestry operations and can be produced while maintaining or improving forest ecosystem services. Ecosystem services are protected by the requirement to utilize loggers trained to apply scientifically based best management practices in planning and implementing harvest for the export market. Bioenergy markets supplement incomes to private rural landholders and provide an incentive for forest management practices that simultaneously benefit water quality and wildlife and reduce risk of fire and insect outbreaks. Bioenergy also increases the value of forest land to landowners, thereby decreasing likelihood of conversion to nonforest uses. Monitoring and evaluation are essential to verify that regulations and good practices are achieving goals and to enable timely responses if problems arise. Conducting rigorous research to understand how conditions change in response to management choices requires baseline data, monitoring, and appropriate reference scenarios. Long-term monitoring data on forest conditions should be publicly accessible and utilized to inform adaptive management

Антикризисное управление

Учебно-методический комплекс (УМК) по учебной дисциплине «Ан-тикризисное управление» создан в соответствии с требованиями Положения об учебно-методическом комплексе на уровне высшего образования, утвер-жденного постановлением Министерства образования Республики Беларусь от 26.07.2011 № 167, предназначен для реализации содержания образова-тельной программы для обучающихся первой ступени высшего образования для студентов специальности 1-26 02-02 «Менеджмент». Содержание разделов УМК соответствует образовательному стандарту высшего образования данной специальности. Главная цель УМК – оказание методической помощи магистрантам в освоении и систематизации учебного материала в процессе обучения и под-готовки к аттестации по дисциплине «Антикризисное управление». УМК включает: 1. Теоретический раздел (конспект лекций, аннотированный перечень основных учебных и научно-практических изданий). 2. Практический раздел (тематика практических занятий по дисци-плине в соответствии с учебным планом и учебной программой). 3. Контроль работы обучающихся (материалы для текущей аттестации, позволяющие определить соответствие учебной деятельности обучающихся требованиям образовательного стандарта высшего образования и учебно-программной документации, в т.ч. вопросы для подготовки к зачету). 4. Вспомогательный раздел (содержание учебного материала учебной дисциплины; методические рекомендации по организации самостоятельной работы магистрантов; информационно-аналитические материалы: список ре-комендуемой литературы, перечень электронных ресурсов и их адреса; при-мерный перечень тем для написания рефератов). Работа с УМК должна включать на первом этапе ознакомление с со-держанием учебного материала учебной дисциплины, посредством которого можно получить информацию о тематике лекций и практических занятий, перечнях рассматриваемых вопросов и рекомендуемой для их изучения ли-тературы. Для подготовки к практическим занятиям необходимо использо-вать материалы, представленные в Теоретическом и Практическом разделах. В основу структуры программы легла учебная программа «Антикри-зисное управление» Белорусского государственного университета для выс-ших учебных заведений по специальности Э.01.03.00 «Экономика и управле-ния на предприятии» (регистрационный № ТД-182/баз.)